Coagulation Factor X
نویسندگان
چکیده
منابع مشابه
Hereditary coagulation factor X deficiency.
Stuart Prower factor (Factor X) deficiency is a rare hereditary autosomal recessive coagulation disorder. We have come across three cases in the course of last 20 years at our institute. These patients presented with prolonged bleeding after minor trauma, epistaxis, subcutaneous bluish black nodules and two of them presented with history of consanguinity in parents. Hematological findings in co...
متن کاملCongenital factor X deficiency of coagulation revealed by epistaxis.
T congenital factor X (FX) is a plasmatic glycoprotein, which plays a crucial role in coagulation. Its deficit is among rare causes of the hemorrhage in child. It could be acquired or congenital. The main hemorrhagic manifestations are epistaxis, hematuria, and menorrhagia in females, sometimes hemarthrosis even craniocerebral hemorrhage. The measurement of the FX rate in the blood allows the d...
متن کاملCarbohydrate residues modulate the activation of coagulation factor X.
Factor X is a plasma protein involved in both the intrinsic and extrinsic pathways of blood coagulation. Post-translational modifications of the protein involve gamma-carboxylation of specific glutamic acid residues, beta-hydroxylation of one aspartic acid residue, and N- and O-linked glycosylation. Even though it is known that gamma-carboxylation is instrumental in regulating biological activi...
متن کاملPathways in the activation of human coagulation factor X.
Purified human Factor X (apparent mol.wt. 72000), which consists of two polypeptide chains (mol.wt. 55000 and 19000), was activated by both Russell's-viper venom and the purified physiological activators (Factor VII/tissue factor and Factor IXa/Factor VIII). They all convert Factor X to catalytically active Factor Xa (mol.wt. 54000) by cleaving the heavy chain at a site on the N-terminal region...
متن کاملNonsense-mediated mRNA decay among coagulation factor genes
Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. The clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. Clotting insufficiency mostly occurs due to genetically inherited coagulation fact...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1996
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.24.1-2_1